The frequent emergence of antibiotic resistance challenges modern medicine. It is very important to discuss the evolution of resistance to curb its global spread. The evolution of resistance involves a highly complex phenotypic heterogeneous response. Under the treatment of antibiotics, a small number of antibiotic-tolerant cell subsets will appear in the microbial flora with identical genes. The surviving subgroup can’t grow in the presence of antibiotics, but it can grow again after removing antibiotics, resulting in long-term recurrent infection, which is also the key reservoir for subsequent mutation of resistance genes. However, due to the complex heterogeneous response and stagnant growth of tolerance subgroups, it is still a challenge to identify tolerance subgroups from a large number of bacterial populations and track their physiological evolution trajectory.　
　　Recently, the team of Academician Zhu Yongguan from the Institute of Urban Environment, Chinese Academy of Sciences and Cui Li’s research group published in German Applied Chemistry. A research paper entitled an isotope-labeled single-cell Raman spectroscopy approach for tracking the physiological evolution of bacteria towards biological resistance was published. In this study, the heterogeneity of bacterial response was analyzed in situ at a high-precision level by developing a combination of single-cell Raman-deuterium isotope-multivariate statistical analysis, and the differentiation and dynamic changes of phenotypic subsets were sensitively identified from a large number of bacterial populations, which realized the rapid in-situ tracking of bacterial phenotypic physiological trajectory before resistance mutation, providing important guidance for curbing resistance evolution.　
　　In this study, bacteria were repeatedly exposed to clinical therapeutic doses of antibiotics, and antibiotic resistance evolved. In this paper, the in-situ activity of bacteria during evolution was detected by Raman spectroscopy of single cells labeled with heavy water in a culture-independent way. The results showed that the activity of bacteria under antibiotic pressure gradually increased with the treatment cycle without resistance mutation, indicating that its phenotypic tolerance gradually improved. Furthermore, the study uses UMAP multivariate statistical algorithm to analyze the single cell Raman fingerprint interval of thousands of bacteria in all evolutionary stages. According to the physiological response of bacterial phenotype indicated by Raman fingerprint, four phenotypic subgroups differentiated with the evolution of resistance were identified from bacterial populations with identical initial genotypes, namely sensitive flora, primary tolerant bacteria, evolution tolerant bacteria and evolution resistant bacteria, and the dynamic changes of the four subgroups with the evolution process were sensitively captured. So far, based on the heterogeneous response of bacteria in situ phenotype revealed by single cell Raman, researchers have drawn a physiological trajectory map of resistance evolution. Genome-wide sequencing of bacteria verified the revealed phenotype interactively, and analyzed the genetic basis of phenotype. Phenotypic differentiation is very important to maintain the survival and evolution of the whole flora. Because phenotypic differentiation is much earlier than resistance mutation, identifying phenotypic differentiation is of great significance for guiding clinical medication and reducing the occurrence of antibiotic tolerance and resistance mutation. In this study, the Raman spectra of four distinct subgroups were used to dig out the Raman marker peaks of tolerance and resistance mutation, which promoted the rapid and accurate identification of different stages of resistance evolution, especially phenotypic tolerance.　
　　The single cell analysis platform can be extended to a wider range of research on the evolution of resistance induced by antibiotics or non-antibiotic chemicals. In the future, the single-cell Raman can be combined with targeted single-cell sorting and multi-omics technology to realize the accurate correlation between tolerance and resistance phenotype and genotype, and promote the further explanation of evolutionary mechanism. The research work is supported by the "0 to 1" original innovation project of Chinese Academy of Sciences, the innovative research group project of National Natural Science Foundation of China and Fujian Natural Science Foundation.　
　　Paper link　
　　Tracking the evolution of bacterial antibiotic resistance by single cell Raman-isotope labeling-multivariate statistical analysis

"Tired, have a rest."

In Chengdu Qingbaijiang Micro-products Liandahai Industrial Park, truck driver Ye Qinghua took advantage of the cargo gap and walked into the 24-hour "rest station". The temperature in the station is suitable, and the facilities and equipment are readily available. Ye Qinghua opened the refrigerator, took out a bottle of frozen mineral water and gulped it down. "It’s very convenient here. The canteen next door also provides meals of 2 meats, 2 vegetarian dishes and 1 soup. You can eat them for free by scanning the code."

Qingbaijiang is the seat of Chengdu International Railway Port, and the trains between China and Europe (Chengdu and Chongqing) are galloping, attracting many modern logistics enterprises to settle down and simultaneously expanding the group of truck drivers. As one of the busiest logistics industrial parks in Chengdu, Dahai ranks first in the city in terms of storage capacity, distribution capacity and truck flow. Every day, thousands of trucks loaded with goods come in and out from here, transporting tens of thousands of tons of goods between Chengdu and other cities.

The "rest station" in Chengdu Qingbaijiang Dahai Industrial Park. Photo courtesy of Dahai Industrial Park

In view of the characteristics of large mobility and scattered aggregation of truck drivers. In 2022, Dahai Industrial Park opened the "Rongouyi Warm Heart House", which provided one-stop services such as parking and maintenance to meet the needs of truck drivers who want to "drink hot water, eat hot meals, take a hot bath and sleep well". Last year, combined with the business model of truck drivers in the park, Dahai Industrial Park launched several "rest stops", with air conditioners, televisions, water dispensers, recliners, books and newspapers, which further upgraded the service model of "Warm Heart Home". According to Li Lianglun, director of Chengdu Dahai Comprehensive Management Department, after the launch of the "rest station", truck drivers use the station service more than a thousand times a month.

The "rest post" has perfect internal functions and facilities. Photo courtesy of Dahai Industrial Park

Since 2021, Sichuan has explored a new path of high-quality development of the industry with "wheel party building", and innovated to create an upgraded version of the driver’s home-the "warm-hearted home" for truck drivers. At present, 26 related points have been built. According to the person in charge of the Sichuan Provincial Department of Transportation, the "Warm Home" is laid out along highways, ordinary national and provincial roads, logistics parks and inland ports in the province. According to the plan, 37 "Warm Home" points will be built in Sichuan before 2025, realizing full coverage of the main freight logistics channels in the province. On the basis of broadening the points, more considerate services are also being launched.

Jintang Service Area of Chengde South Expressway has established the first "warm-hearted home" for truck drivers in the province. In the "warm-hearted home", the laundry and drying area, shower area and kitchen area are well-equipped, providing drivers and passengers with services such as bringing their own bedding to stay at the minimum of one yuan, and the "one meat and two vegetables" box lunch sold in the service area is at the minimum of ten yuan, striving for convenience and practicality.

"This is the warm home of our truck driver."

"The space is clean, the service is good, the bath is very comfortable, and the mood of the sports car is good."

……

On the register of "Warm Heart House", the truck driver expressed his affirmation of this service through a series of real messages.

On this basis, in 2023, the Jintang service area of Chengde South Expressway launched the Warm Heart Health Service Station, which opened up a safe, healthy and green rescue channel to provide health promotion, emergency rescue and safety guarantee to the drivers and passengers in the past service areas.

Warm Heart Health Service Station is equipped with automatic external defibrillator (AED), sphygmomanometer and standing medicine box. Jintang Service Area, in conjunction with county transportation department and health department, has opened a medical green rescue channel nearby and provided a special telephone for green rescue. In case of emergency, the service area staff can contact the local hospital ambulance personnel and quickly link to medical resources, so that the drivers and passengers who are in urgent need of treatment can get the most timely and fastest medical treatment.

Warm heart health service station in Jintang service area of Chengde South Expressway. Photo courtesy of service area

In January of this year, Ms. Wang, a driver and passenger, was sent to the post station by her friends because she was flustered, short of breath and weak. In the post station, the staff gave Ms. Wang a simple care and contacted the hospital through the emergency phone. It took only 14 minutes. The ambulance arrived at the post station and transferred Ms. Wang to the hospital for treatment.

"The service station is committed to rapid discovery, timely treatment and effective treatment of patients, and provides a safe and healthy travel service experience for drivers and passengers in all directions." According to Yue Dongxue, director of Jintang Service Area of Chengde South Expressway, in the early stage, they conducted emergency rescue skills training to improve the self-help and mutual rescue ability of the service area in response to emergencies and accidental injuries. It is convenient for rapid discovery, timely treatment and effective treatment of patients. "Provide a safe and healthy travel service experience for drivers and passengers in all directions." She said.

Noisy and boiling fireworks and oily kebabs stimulate the taste buds … When it comes to the special food in Gejiu City, Honghe Hani and Yi Autonomous Prefecture, Yunnan Province, barbecue is inevitable. By the side of the oven surrounded by fireworks, a bench was set up to sit around a table, and a variety of ingredients were "baked" under the charcoal fire.

Small kebab.

Kebab

The kebab is the protagonist of an old barbecue. The pork leg cut to the size of rock sugar is put on a bamboo stick of about 10 cm, and it is roasted by charcoal fire to be golden, shiny, moist and not greasy. It is very enjoyable. An old man who likes to be sweet likes to wrap small kebabs in powdered sugar and then send them to China with satisfaction. The unique rich meat flavor of barbecue is mixed with the sweet and spicy spices, which teases the taste buds.

Hanging liver meat

A plate full of meat is spread on the grill, and you can eat which piece you want. The lean meat full of aroma is wrapped in chewy meat tendons. After roasting, the aroma of meat, charcoal and seasoning is fully integrated, and the aroma is overflowing.

A barbecue that is being baked.

Honey beef

Beef, honey, pepper and many seasonings make the honey beef skewers rich and wonderful in taste. The savory kebabs marinated by the exclusive secret recipe meet with the beating fireworks, and the meat particles are soft, tender and fragrant, intertwined with sweet and spicy, giving the taste buds great enjoyment.

Gedachang

An old man has never been stingy with his food, and even his intestines are baked with originality. The so-called knot in one’s heart sausage is to tie a delicate knot in the pig’s small intestine and sprinkle it with rich seasonings. The refreshing taste of glutinous rice balls makes people want to stop.　

Baked tofu.

Baked tofu

Gejiu’s baked tofu has a variety of styles, including wrapped tofu, dried tofu and stinky tofu, which are constantly "turned over" on the stove and slowly roasted. Diners sit around the stove, bake one piece and then take it away. They wrap a circle in the oil dish and the Chili dry dish and send it to the mouth. The bean, oil and Chili flavors collide to produce a wonderful taste.

The delicious food being baked.

In midsummer, it’s nice to have a hot barbecue with three or five friends. Gejiu barbecue is a dance of oil and meat on the tip of the tongue, a perfect combination of charcoal roasting and sauce blending, and it has become a hot comfort in ordinary life.

Source: Gejiu Rong Media Center

　

　　CCTV News:On July 25 th, the "International Sharp Review" of the Central Radio and Television General Station broadcasted the title "Who is the White House in a hurry to send checks to farmers?" The article was reprinted and published by many overseas media.

　　On July 25th and 26th, Germany’s "German-Chinese Report" website, Spain’s Global Iberian Media Client, Italy’s RADIOWE website (facebook, twitter), Portugal’s Lisbon Rainbow Radio website (facebook), Brazil’s Sao Paulo World Radio and Television website (facebook), Brazil’s Rio Headline Radio and Television website (facebook), Brazil’s Romantic Radio website, Brazil’s Business Observer website, Many overseas media, such as Ururau newspaper website, Indian Daily Morning News website, Turkish Economic Observation Network, Chinese PT portal, Chinese headline APP, Portuguese New Newspaper APP(facebook, twitter), European Union Chinese website, West Africa online website, Africa Times website, Greek China website, Japanese Chinese business website and so on, have forwarded them one after another. On 26th, Hong Kong Ta Kung Pao and Wen Wei Po published this article. The main reports are as follows:

　　US President Trump said on Tuesday that he would provide an agricultural subsidy of up to $12 billion to help American farmers tide over the growing trade war between the United States and China, the European Union and other countries.

　　Prior to this, one of the reasons why the United States provoked trade wars with many trading partners was that their products exported to the United States had so-called government subsidies. Now, the White House has also begun to issue subsidies. Isn’t this hitting yourself in the face? ! Trump’s move once again proves that economists have always warned the White House, that is, "there is only a double loss in the trade war, and there is no winner."　

　　The essence of trade is win-win, whether it is cooperation or competition. However, this US administration seems to be paranoid and firmly believes that trade is a zero-sum game. Obviously, I bought bread to fill my stomach, and I have to accuse the bread seller of being a winner and a loser. This logic is too twisted!

　　The White House’s use of taxpayers’ huge funds as agricultural subsidies is the inevitable result of its imposition of punitive tariffs on goods from global trading partners, which eventually leads to retaliation from many parties. Among them, the American agricultural economic belt is one of the key targets of retaliatory measures by various countries. Those American farmers are precisely the victims of Trump’s trade war, and they are swallowing the consequences of the irrational and outrageous tariff policy of the White House.

　　As the world’s largest exporter of agricultural products, the export of agricultural products in the United States reached a record high in 2017, with a trade surplus of $21.3 billion. Since the trade war, trading partners including EU, Canadian, Mexican and China have been forced to impose retaliatory tariffs on agricultural products originating from the United States. The USDA estimates that these countermeasures will cause about $11 billion in losses to American agricultural products.

　　The United States has always accused other countries of subsidy policies, saying that this practice violates the provisions of the WTO. Now, the White House has picked up taxpayers’ money and done what it has always been illegal in its own eyes. In a sense, this is also a set of votes for the mid-term elections in November this year. This sanctimonious double standard is overbearing: "Only I can set fire, but you can’t light a lamp".

　　However, can the White House check really solve its problem? As Blake Horst, director of the Missouri Department of Agriculture, said, unless the White House policy changes, the pressure on American agriculture will continue. Short-term or temporary remedial measures cannot solve the substantive problems. Brian Kuhl, executive director of Farmers for Free Trade, believes that American farmers need contracts instead of subsidies, and with contracts, they can make plans for the future with peace of mind.

　　Previously, Trump believed that the trade war would be beneficial to the US, and the trade war would be easy to fight and win. Today’s results show that things are not as simple as he thought. This is because the US government’s subsidies to agriculture will inevitably bring out a series of related problems. Alaska Senator Lisa Mokowski is asking: What about manufacturing? Energy field? What about oil and gas industry? What is the standard of subsidy or not?

　　The New York Times pointed out in the editorial that those manufacturers who need to pay high prices for steel and aluminum because of the trade war need subsidies? Do workers who are unemployed because Harley-Davidson motorcycles transfer production lines need subsidies? Do producers of bourbon affected by the trade war need subsidies?

　　If the United States continues to subsidize other industries affected by the trade war, then the Trump administration will face many challenges, on the one hand, the problem of money bags, on the other hand, the legitimacy of subsidies. As for the legality of the latest US$ 12 billion subsidy, it is estimated that many countries will submit it to the WTO for adjudication.

　　In fact, the White House is very clear about how to solve the situation. Republican Senator Ben Sass said that a trade war is like cutting farmers’ legs, and then the White House plan is to give them a pair of pure gold crutches worth $12 billion. "The government’s tariffs and relief will not make the United States great again, but will come again in 1929 (the Great Depression)."

　　Senator rand paul tweeted: "Tariffs are equivalent to increasing taxes on American consumers and producers. If tariffs punish farmers, then the answer is not welfare, but the abolition of tariffs. "

　　Analysts pointed out that the United States continued the tariff war by granting subsidies to farmers. On the one hand, it reflected its double standards and "two-faced" approach in international trade, which showed the hypocrisy and hegemony of the United States. On the other hand, it also reflected the Don Quixote-style approach of the United States, which not only created a lot of uncertainty for other countries, but also endangered the global multilateral trading system and brought serious chaos to its own country.

　　A number of overseas media forwarded international critical articles:

The German "German-Chinese Report" website was forwarded on July 25, 2018

　　Spain Universal Iberian Media Client forwarded on July 25, 2018

　　Italian RADIOWE website (facebook, Twitter) forwarded on July 25, 2018.

　　Portugal Lisbon Rainbow Radio website (Facebook) forwarded on July 25, 2018.

　　Brazilian "Business Observer" website forwarded on July 25, 2018

　　India’s "Daily Morning News" website was forwarded on July 25, 2018

　　Forward by Turkish Economic Observer Network on July 25, 2018

　　Portuguese news APP(facebook, Twitter) forwarded on July 26, 2018.

　　Hong Kong Ta Kung Pao was published on July 26, 2018

　　Hong Kong Wen Wei Po was published on July 26, 2018.

Catalogue

　　The first part of the 2019 annual departmental final accounts report

　　I. Summary of final accounts of income and expenditure

　　Second, the income statement

　　Iii. Final Statement of Expenditure

　　IV. Summary of Final Accounts of Financial Appropriation Income and Expenditure

　　V. Final Statement of General Public Budget Financial Allocation Expenditure

　　VI. Final Statement of Basic Expenditure of General Public Budget Financial Allocation

　　Seven, the government fund budget financial allocation income and expenditure statement.

　　Eight, the government fund budget financial allocation of basic expenditure statement

　　Nine, the financial allocation "three public" expenditure statement

　　X. Table of Government Procurement

　　XI. Table of Government Expenditure on Purchasing Services

　　The second part of the 2019 annual departmental accounts

　　Part III Information on Other Important Matters in 2019

　　The fourth part is the performance evaluation of departments in 2019

The first part of the 2019 annual departmental final accounts report

　　See the attachment for the report.

The second part of the 2019 annual departmental accounts

　　I. Basic information of the department

　　(1) Main functions

　　The Beijing Municipal Health and Wellness Commission (hereinafter referred to as the Municipal Health and Wellness Commission) is an integral part of the municipal government responsible for the health and wellness work in this Municipality. Main responsibilities include:

　　1. Responsible for drafting health-related local regulations and government regulations. Plan and coordinate the allocation of health service resources in Beijing as a whole, and formulate and organize the implementation of regional health development plans. Coordinate and promote health information and statistics.

　　2 responsible for organizing and coordinating the reform of medical and health system, studying and formulating the planning, policies, implementation plans and related supporting measures for the reform of medical and health system. Formulate and organize the implementation of policies and measures to promote the diversification of health service providers and ways of providing health services. To study and put forward policy suggestions on medical services and drug prices.

　　3. Responsible for disease prevention and control. Formulate disease prevention and control plans, immunization plans and intervention measures for public health problems that seriously endanger residents’ health, and organize their implementation. Responsible for the construction and management of the city’s health emergency system. Formulate health emergency and emergency medical rescue plans, public health emergency monitoring and risk assessment plans, organize and guide the prevention and control of public health emergencies and medical and health rescue of various public emergencies.

　　4. Organize and coordinate the implementation of national and municipal policies and measures to deal with population aging, and be responsible for organizing and promoting the construction of health service system for the elderly and the combination of medical care and nursing.

　　5 responsible for the implementation of the national drug policy and the national essential drug system in this Municipality, organize the implementation of the national essential drug list, and carry out drug use monitoring, clinical comprehensive evaluation and early warning of drug shortage in this Municipality. Organize food safety risk monitoring and evaluation in this city.

　　6. Be responsible for the supervision and management of public health such as occupational health, radiation health, environmental health, school health, public place health, drinking water health, etc. within the scope of responsibilities of this Municipality, be responsible for the supervision of infectious disease prevention and control in this Municipality, and improve the comprehensive health supervision system.

　　7 responsible for the supervision and management of the medical and health industry in this Municipality. To organize the formulation of norms and standards for medical institutions and their medical treatment, rehabilitation, nursing services and medical technology, medical quality, medical safety and management of blood collection and supply institutions, and supervise their implementation. To organize the formulation of medical and health professional ethics standards and regulations on the practice management of medical personnel. Establish a service evaluation and supervision system for medical treatment, rehabilitation, nursing and public health. To undertake the relevant management work of encouraging social forces to provide medical and health services. Building a harmonious relationship between doctors and patients.

　　8 responsible for the city’s family planning management and service work. Organize the monitoring of the birth population dynamics in this city, and put forward suggestions on releasing the information of population monitoring, early warning and forecasting in this city. Organize the implementation of the city’s family planning policy.

　　9. Responsible for formulating and organizing the implementation of policies and measures for grassroots health, maternal and child health, elderly health and mental health in this Municipality, and guiding the construction of grassroots health, maternal and child health, elderly health and mental health system in this Municipality. We will promote the equalization of basic public health and health services for the elderly, and improve the new mechanism for grass-roots operation and the management system for rural doctors and general practitioners. Organize patriotic health campaigns and health promotion actions. Participate in promoting the innovation and development of health science and technology.

　　10. Be responsible for the health care work of the health care objects of this Municipality and the health care objects of the central units with medical relations in this Municipality. Responsible for the management of medical care for cadres in various departments of the city and district. Participate in the organization and implementation of medical and health security tasks for major events held in this city.

　　11. Manage the Beijing Administration of Traditional Chinese Medicine, manage the Beijing Association of Aging, and manage the Beijing Hospital Management Center.

　　12. Complete other tasks assigned by the municipal party committee and municipal government.

　　(II) Institutional situation

　　There are 28 departments, namely: Office, Development Planning Department (Capital Medical and Health Coordination Department), Policy and Regulation Department, System Reform Department, Disease Prevention and Control Department (Public Health Management Department), Medical Administration Department (Social Medical Service Department), Patriotic Health Campaign Promotion Department (Health Promotion Department), Grassroots Health Department, Health Emergency Office (Emergency Command Center for Public Health Emergencies), Science and Technology Education Department and Comprehensive Supervision Department. Health Department for Aging, Maternal and Child Health Department, Occupational Health Department, Population Monitoring and Family Development Department, Public Rights Protection Department, International Cooperation Department (Hong Kong, Macao and Taiwan Office), Health Care Department (Beijing Municipal Health Commission Office), Poverty Alleviation Cooperation and Support Department, Information Statistics Department, Finance Department (Audit Department), Cadre and Personnel Department (Talent Department), Party Committee (Party-Mass Work Department) and Discipline Inspection Commission (Inspection Office).

　　The 42 budget units are: Beijing Municipal Health and Wellness Commission, Beijing Municipal Health and Wellness Commission Retired Cadre Service Center, Beijing Family Planning Service Guidance Center, Beijing Family Planning Association, Beijing Institute of Hepatology, Beijing Rural Water Improvement Leading Office, Beijing patriotic health campaign committee Office, Beijing Health and Wellness Supervision Office, Beijing Diabetes Research Institute, Beijing Health and Wellness Commission Publicity Center, Beijing Maternal and Child Health Hospital, Beijing Health Vocational College, Beijing Health and Wellness Commission Accounting Service Center, Beijing Health and Wellness Commission Information Center, Beijing Community Health Service Management Center, Capital Institute of Pediatrics, Beijing Institute of Otolaryngology, Beijing Institute of Ophthalmology, Beijing Institute of Tuberculosis and Chest Tumor, Beijing Institute of Cardiopulmonary Vascular Diseases, Beijing Institute of Traditional Chinese Medicine, Beijing Institute of Pediatrics, Beijing Institute of Traumatology, Beijing Institute of Clinical Medicine, Beijing Research Center of Preventive Medicine, Beijing Institute of Cancer Prevention and Treatment, Beijing Institute of Traditional Chinese Medicine.Service Center, Beijing Institute of Tropical Medicine, Beijing Geriatric Medical Research Center, Beijing Institute of Respiratory Diseases, Beijing Emergency Center, Beijing Center for Disease Control and Prevention, Beijing Institute of Tuberculosis Control, Beijing Red Cross Blood Center, Beijing Branch of Chinese Medical Association, Beijing Physical Examination Center, Beijing Municipal Health and Wellness Commission Talent Exchange Service Center, Party School of Beijing Municipal Health and Wellness Commission, Beijing Mental Health Care Institute, Beijing Aging Association, and Beijing Municipal Health and Wellness Commission Administrative Examination and Approval Service Center.

　　(II) Personnel composition

　　The administrative establishment of this department is 344, and the actual number is 342; There are 5,120 employees, and there are 4,027 employees.

　　Second, the overall situation of income and expenditure accounts

　　In 2019, the total revenue and expenditure was 7,971,314,200 yuan, an increase of 1,495,034,100 yuan or 23.08% over the previous year.

　　(a) the income statement

　　In 2019, the total revenue this year was 6,912,643,800 yuan, an increase of 1,014,604,900 yuan over the previous year, with an increase of 17.20%, of which: the revenue from financial allocation was 4,518,216,900 yuan, accounting for 65.36% of the total revenue; Superior subsidy income is 0 million yuan; Business income is 2,100,811,500 yuan, accounting for 30.39% of the total income; Operating income is 4,861,600 yuan, accounting for 0.07% of the total income; The income paid by the affiliated unit is RMB 0,000; Other income was 288,753,800 yuan, accounting for 4.18% of the total income.

　　(2) Description of final accounts of expenditures

　　In 2019, the total expenditure this year was 6,344,633,900 yuan, an increase of 814,396,500 yuan or 14.73% over the previous year, of which: the basic expenditure was 3,754,880,900 yuan, accounting for 59.18% of the total expenditure; The project expenditure is 2,585,535,200 yuan, accounting for 40.75% of the total expenditure; Paid to the superior expenditure of 0 million yuan; Operating expenditure was 4,217,800 yuan, accounting for 0.06% of the total expenditure; Subsidy expenditure for affiliated units is 0,000 yuan.

　　Three, the financial allocation of income and expenditure accounts of the overall situation

　　In 2019, the total revenue and expenditure of financial allocation was 4,804,481,100 yuan, an increase of 544,878,100 yuan or 12.79% over the previous year.

　　Four, the general public budget expenditure accounts.

　　(a) the overall situation of the general public budget expenditure accounts

　　In 2019, the financial allocation expenditure of the general public budget was 3,848,889,600 yuan, which was mainly used in the following aspects (according to major categories): the education expenditure was 478,239,700 yuan, accounting for 12.43% of the financial allocation expenditure this year; The expenditure on science and technology is 1,027,268,400 yuan, accounting for 26.69% of this year’s financial allocation; The expenditure on culture, tourism, sports and media is 1,284,200 yuan, accounting for 0.03% of this year’s financial allocation; Expenditure on social security and employment was 37,315,400 yuan, accounting for 0.97% of this year’s financial allocation expenditure; Health expenditure was 2,304,781,900 yuan, accounting for 59.88% of this year’s financial allocation.

　　(two) the specific situation of the final accounts of the general public budget.

　　1. The final account of "education expenditure" in 2019 was 478,239,700 yuan, a decrease of 278,124,000 yuan or 36.77% compared with the budget at the beginning of 2019.

　　Among them:

　　The final account of "General Education" in 2019 was 130,631,500 yuan, a decrease of 283,093,800 yuan or 68.43% compared with the budget at the beginning of 2019. The main reason: the construction project of the new campus of Health Vocational College is a continuous project, which was not completed in the current year and was carried forward to the next year for further implementation.

　　The final account of "Vocational Education" in 2019 was 250,022,700 yuan, an increase of 14,741,100 yuan or 6.27% compared with the budget at the beginning of 2019. The main reason: The main reason: according to the development of the work, increase the special funds for the construction of characteristic majors.

　　The final account of "Further Education and Training" in 2019 was 97,585,500 yuan, a decrease of 9,771,300 yuan or 9.10% compared with the budget at the beginning of 2019. The main reasons are: implementing the work requirements of the municipal party Committee and municipal government, and reducing general expenditures such as training.

　　2. The final account of "science and technology expenditure" in 2019 was 1,027,268,400 yuan, an increase of 23,297,600 yuan or 2.32% compared with the budget at the beginning of 2019.

　　Among them:

　　The final account of "Applied Research" in 2019 was 850,354,100 yuan, an increase of 27,113,300 yuan or 3.29% compared with the budget at the beginning of 2019. The main reason: during the budget implementation, the funds for the pilot project of public welfare development and reform in Beijing municipal medical research institutes were increased.

　　The final account of "Science and Technology Conditions and Services" in 2019 was 3,251,800 yuan, a decrease of 1,327,400 yuan or 28.99% compared with the budget at the beginning of 2019. The main reason: the project was not spent in the current year, and it was carried forward to the next year for continued use.

　　The final account of "other scientific and technological expenditures" in 2019 was 173,662,500 yuan, a decrease of 2,488,300 yuan or 1.41% compared with the budget at the beginning of 2019. The main reason: according to the relevant regulations of scientific research project management, funds can be used across years, and some scientific research projects are not spent in the current year according to the project progress, and are carried forward to the next year to continue implementation.

　　3. The final account of "cultural tourism, sports and media expenditure" in 2019 was 1,284,200 yuan, a decrease of 13,200 yuan or 1.02% compared with the budget at the beginning of 2019. Among them:

　　The final accounts of "cultural relics" in 2019 were 1,284,200 yuan, a decrease of 13,200 yuan or 1.02% compared with the budget at the beginning of 2019. The main reason: the net balance generated after the completion of the cultural relics repair project of the Party School of the Municipal Health and Wellness Committee.

　　4. The final account of "Social Security and Employment Expenditure" in 2019 was 37,315,400 yuan, a decrease of 134,000 yuan or 0.36% compared with the budget at the beginning of 2019. Among them:

　　The final account of "Retirement of administrative institutions" in 2019 was 37,315,400 yuan, a decrease of 134,000 yuan or 0.36% compared with the budget at the beginning of 2019. The main reason: some retired workers died in the middle of the year, resulting in a certain balance of retirement funds.

　　5. The final account of "health expenditure" in 2019 was 2,304,781,900 yuan, an increase of 149,832,100 yuan or 6.95% compared with the budget at the beginning of 2019.

　　Among them:

　　The final account of "Health Management Affairs" in 2019 was 415,602,300 yuan, a decrease of 28,432,900 yuan or 6.40% compared with the budget at the beginning of 2019. The main reason: according to the work requirements of the municipal party Committee and municipal government, the general expenses such as office expenses of organs and subordinate units under this subject were reduced.

　　The final accounts of "public hospitals" in 2019 were 389,172,000 yuan, an increase of 136,872,500 yuan or 54.25% over the budget at the beginning of 2019. The main reasons are: in the middle of the year, the central government subsidized the capacity building of local medical and health institutions, the central government subsidized the construction of regional medical centers and the relocation of Beijing Center for Disease Control and Prevention.

　　The final account of "Public Health" in 2019 was 1,391,937,900 yuan, an increase of 42,373,800 yuan or 3.14% over the budget at the beginning of 2019. The main reasons are: in the middle of the year, the prevention and control capacity building project of emergency center was added, the pre-hospital emergency service project of 999 was purchased, and the vehicle-mounted system of 120 system of Beijing Emergency Center was purchased.

　　The final account of "Family Planning Affairs" in 2019 was 74,509,100 yuan, an increase of 132,100 yuan or 0.18% over the budget at the beginning of 2019. The main reason: according to the actual work in the middle of the year, the difference between the funds of the warm heart plan was added.

　　The final account of "Health Affairs for the Aged" in 2019 was RMB30,284,200, an increase of RMB81,000 or 0.27% over the budget at the beginning of 2019. The main reason: basic funds such as social security contributions for new employees were added in the middle of the year.

　　The final account of "other health expenditure" in 2019 was 3.2764 million yuan, a decrease of 1.1944 million yuan or 26.72% compared with the budget at the beginning of 2019. The main reason: according to the work requirements of the municipal party Committee and municipal government, the general expenses such as office expenses of organs and subordinate units under this subject were reduced.

　　Five, the government fund budget expenditure accounts.

　　There is no such expenditure this year.

　　Six, the financial allocation of basic expenditure accounts.

　　In 2019, the department allocated 1,597,592,600 yuan in general public budget and 0,000 yuan in government funds, including: (1) salary and welfare expenses including basic salary, allowances, bonuses, food subsidies, performance pay, other social security contributions and other salaries and benefits; (2) Expenditure on goods and services includes office expenses, printing fees, consulting fees, handling fees, water fees, electricity fees, post and telecommunications fees, heating fees, property management fees, travel expenses, expenses for going abroad (abroad) on business, maintenance (protection) fees, rental fees, conference fees, training fees, official reception fees, special materials fees, labor fees, entrusted business fees, trade union funds, and so on. (3) Subsidies for individuals and families include retirement expenses, retirement expenses, pensions, living allowances, relief expenses, medical expenses subsidies, grants, bonuses and other subsidies for individuals and families. (4) Other capital expenditures include the purchase of office equipment and special equipment.

Part III Information on Other Important Matters in 2019

　　First, the "three public funds" financial allocation final accounts

　　The "three public" funds include two administrative units, two institutions that refer to the civil service law and 20 institutions. In 2019, the final accounts of the "three public" funds were 4,553,600 yuan, a decrease of 1,739,800 yuan compared with the budget of 6,293,300 yuan at the beginning of 2019. Among them:

　　1. Expenses for going abroad on business. The final accounts in 2019 were 2,350,500 yuan, a decrease of 153,400 yuan compared with the budget of 2,503,900 yuan at the beginning of 2019. The main reasons are: compressing and integrating overseas delegations and training days, improving the efficiency of visiting and reducing the funds for going abroad; In 2019, the expenses for going abroad on business were mainly used for the grass-roots health delegation of Beijing Municipal Health and Wellness Commission, the key exchange project of the Exchange Bureau of the Taiwan Affairs Office of the State Council, the group of Beijing Municipal Health and Wellness Commission going to Guinea, and the group of Beijing Municipal Health and Wellness Commission going to Israel. In 2019, 32 and 74 people went abroad on business, and the per capita expenses for going abroad on business were 31,800 yuan.

　　2. Official reception fee. The final accounts in 2019 were 47,200 yuan, a decrease of 198,900 yuan compared with the budget of 246,100 yuan at the beginning of 2019. The main reasons: strictly control the expenditure of the three public funds and reduce the reception scale and expenditure. In 2019, the official reception fee was mainly used for official reception work such as Shaanxi Provincial Government’s investigation in Beijing, Shanghai Health and Health Commission and Medical Insurance Bureau’s investigation in Beijing. There were 88 official receptions and 960 official receptions.

　　3 official car purchase and operation and maintenance fees. The final accounts in 2019 were 2,155,900 yuan, a decrease of 1,387,400 yuan compared with the budget of 3,543,300 yuan at the beginning of 2019. Among them, the final account of the official car purchase fee in 2019 was 157,800 yuan, a decrease of 180,000 yuan compared with the budget of 337,800 yuan at the beginning of 2019. The main reasons are: practicing economy and reducing the funds of the three public funds. In 2019, one car was purchased, and the average purchase cost of the car was 157,800 yuan. The final account of the official vehicle operation and maintenance fee in 2019 was 1,998,100 yuan, a decrease of 1,207,400 yuan compared with the budget of 3,205,500 yuan at the beginning of 2019. The main reasons are: strict control of the three public funds and reduced expenditures. In 2019, the official vehicle operation and maintenance fee included 457,300 yuan for refueling, 641,900 yuan for maintenance, 420,000 yuan for insurance and 478,900 yuan for other expenses. In 2019, the number of official vehicles was 134, and the average vehicle operation and maintenance cost was 14,900 yuan.

　　II. Expenditures for the operation of organs

　　In 2019, the daily public expenditure of the basic expenditure arranged by the administrative units of this department (including the administrative institutions with reference to the Civil Service Law) using the financial allocation from the general public budget totaled 14,673,600 yuan, an increase of 3,216,200 yuan over the previous year. The reason for the increase is that according to the institutional reform plan of the municipal government, the Beijing Association for the Aged newly transferred to our Committee is a participating unit, with one administrative unit added and the daily public expenditure increased.

　　Iii. Government procurement expenditure

　　In 2019, the total government procurement expenditure of this department was 619,503,300 yuan, including 314,216,900 yuan for goods, 13,837,400 yuan for projects and 291,449,100 yuan for services. The contract amount awarded to small and medium-sized enterprises was 377,436,000 yuan, accounting for 60.93% of the total government procurement expenditure, of which the contract amount awarded to small and micro enterprises was 101,471,600 yuan, accounting for 16.38% of the total government procurement expenditure.

　　IV. Occupation of State-owned Assets

　　In 2019, there were 491 vehicles in this department, with 286,947,100 yuan; There are 206 sets of general equipment with a unit value of more than 500,000 yuan and 502 sets of special equipment with a unit value of more than 1 million yuan.

　　Five, the state-owned capital operating budget financial allocation revenue and expenditure

　　There is no such expenditure this year.

　　VI. Explanation of government expenditure on purchasing services

　　In 2019, the final account of government procurement services of this department was 116,893,800 yuan.

　　VII. Interpretation of technical terms

　　1. "Three Public Funds": refers to the expenses for going abroad (abroad), purchasing and operating official vehicles and official reception arranged by the unit through financial allocation. Among them, the expenses for going abroad on business refer to the international travel expenses, inter-city transportation expenses, accommodation expenses, meals, training fees, public and miscellaneous expenses, etc. The official vehicle purchase and operation expenses refer to the official vehicle purchase expenses (including vehicle purchase tax and license fee) and the official vehicle fuel expenses, maintenance fees, crossing fees, insurance fees, safety incentive fees and other expenses retained by the unit according to regulations; Official reception fee refers to all kinds of official reception (including foreign guests reception) expenses incurred by the unit according to regulations.

　　2. Operating expenses of organs: refers to the daily public expenditure among the basic expenditures arranged by the administrative units (including the administrative institutions with reference to the Civil Service Law) using the general public budget, including office and printing expenses, post and telecommunications expenses, travel expenses, conference expenses, welfare expenses, daily maintenance expenses, special materials and general equipment purchase expenses, office space utilities, office space heating expenses, office space property management expenses, official vehicle operation and maintenance expenses and other expenses.

　　3. Government procurement: refers to the behavior of state organs, institutions and organizations at all levels using financial funds to purchase goods, projects and services within the centralized catalogue formulated according to law or above the procurement limit standard.

　　4. Government procurement of services: refers to the behavior of state organs at all levels to entrust qualified service providers with services that fall within their own responsibilities and are suitable for market-oriented services in accordance with government procurement methods and procedures, and pay them fees according to factors such as service quantity and quality.

　　5. National immunization program refers to the planned vaccination among the population according to the vaccine varieties, immunization procedures or vaccination programs determined by the state or provinces, autonomous regions and municipalities directly under the Central Government, so as to prevent and control the occurrence and prevalence of specific infectious diseases.

The fourth part is the performance evaluation of departments in 2019

　　First, the performance evaluation work

　　In 2020, the Beijing Municipal Commission of Health and Wellness conducted a performance evaluation of departmental project expenditures in 2019, with 99 evaluation projects, accounting for 20.08% of the total departmental projects, involving an amount of 2.048 billion yuan. Among them, there are 93 summary procedure evaluation projects, involving an amount of 1.598 billion yuan; There are 6 ordinary program evaluation projects involving an amount of 450 million yuan. The performance evaluation of voluntary blood donation publicity funds in the general procedure evaluation project is as follows:

　　Two, blood donation publicity fund project performance evaluation report

　　(A) the evaluation object profile

　　Publicity of voluntary blood donation is the key and prerequisite for doing a good job of voluntary blood donation. In order to ensure sufficient and safe blood use for clinical treatment in the capital, according to the relevant provisions of the People’s Republic of China (PRC) Blood Donation Law, the Beijing Blood Donation Management Measures and the Blood Station Management Measures, since 2006, the municipal finance has allocated special funds for the publicity of blood donation without compensation. In order to ensure the clinical medical safety and adequate blood use in the capital in 2019, especially to ensure the safe, sufficient and timely supply of blood in high temperature, cold seasonal ischemia and emergencies, the knowledge and relevant laws and regulations of blood donation were popularized through various forms of blood donation publicity and mobilization activities throughout the city, so as to improve the awareness and participation of different groups of the public in this city in blood donation, and mobilize all sectors of society to actively participate in blood donation work.

　　(II) Evaluation conclusion

　　According to the implementation of the project, the performance evaluation working group, after comprehensive evaluation by experts, scored a comprehensive score of 88.10 for the performance evaluation of the project of blood donation publicity funds, and the conclusion of the comprehensive performance evaluation of the project was "good".

　　(3) Existing problems

　　First, the project innovation mechanism is insufficient. The project has been implemented for many years since it was established in 2006. However, the publicity methods and means are not innovative enough, and further demonstration and analysis are needed on the publicity forms, planning objectives and realization paths.

　　Second, the completeness and effectiveness of the project implementation plan are insufficient and need to be further refined. In the project implementation plan, the project organization structure, personnel arrangement and project organization mode are not elaborated, so the completeness and effectiveness are insufficient.

　　Third, the project performance target setting can be further improved. Some indicators are not detailed, quantitative and measurable; The benefit indicators are qualitative descriptions, lacking quantitative measurable content, so the quantitative description of benefit indicators should be further increased. In addition, the quantitative indicator value of awareness rate is not set for benefit indicators.

　　(4) Suggestions

　　First, it is suggested to improve the propaganda method and improve the project innovation mechanism. It is suggested to innovate the project management mechanism and organization and implementation mode according to the requirements of the development of the situation, hire a third party to compare and analyze the publicity effects obtained by different media publicity methods, and take various forms and means to carry out publicity activities according to the publicity objects, publicity contents and publicity forms in combination with the present situation and problems of blood donation sources in Beijing, so as to further improve the publicity methods and enhance the publicity effect. It is suggested that the publicity effect should be effectively corresponding to the response rate of blood donors. On the basis of blood donation publicity and investigation in Beijing, scientific, effective and feasible publicity and implementation plans should be formulated, investment in publicity and creativity should be strengthened, and the role of new media should be utilized and brought into play to improve the number of people who donate blood without compensation and the blood donation rate in Beijing.

　　Second, it is suggested to improve the project implementation plan. It is suggested that the project unit should improve the project implementation plan. The project management implementation plan should at least include the necessity, feasibility, performance objectives, financial support, personnel arrangement, time schedule, project organizational structure, personnel allocation, etc. It is suggested that the project unit formulate sub-projects for each work to strengthen the guidance and binding nature of the project implementation plan.

　　Third, it is suggested to strengthen performance target management. It is suggested that the performance management of the project should be strengthened, and the performance objectives of the project should be formulated reasonably. The indicators of the performance objectives should match the contents of the annual project to improve the scientific rationality of the performance indicators.

　　Third, the project expenditure performance self-evaluation form

Huasheng Online March 15 (Reporter Yu Qian) What should I do if there is something wrong with my home appliances? Searching online for brand customer service telephone repair has become the first choice of many consumers. However, seemingly regular 400 telephones are not necessarily official after-sales hotlines, and there are many hidden dangers in on-site maintenance. Recently, a survey conducted by reporters in the columns of "Xiangwen Complaints Through Train" and "Consumer Complaints" found that the threshold for handling "400" calls was low, and the online search shanzhai hotline was given priority recommendation by search engines.

Search the brand "400" phone online.Encounter a "cottage"repair

At the beginning of March, Ms. Liao, a citizen of Changsha, found that the boiling water temperature of Baxi brand wall-hung boiler, which had been used at home for more than ten years, couldn’t get up, so she asked her husband to search the after-sales maintenance hotline of Baxi wall-hung boiler through the Internet and got a number of 4009918883. After dialing, the other party claimed to be the customer service of the manufacturer, so she could leave her address and arrange a maintenance master to come to the door.

A maintenance master who claimed to be sent by the manufacturer came to the door as scheduled. After a simple inspection, the maintenance master said that the controller was broken and needed to be replaced. The motherboard had some problems and needed to be repaired, which cost a total of 1,600 yuan. After some bargaining, the master finally agreed to charge 1000 yuan.

"The master fixed it quickly. After collecting money and adding WeChat, he left without leaving any documents, which was very casual." Ms. Liao recalled that the more she thought about it, the more wrong she was, and she found the official after-sales hotline 4006688700 from the official website of Baxi brand again. When she asked, she learned that she had encountered cottage maintenance, and the official maintenance quotation was actually half cheaper.

Ms. Liao spits out, "We just believe in online search too much. By default, as long as the phone starts with 400, it is formal."

Inconsistent official identification before and after customer service is false after-sales

On March 14th, according to the telephone provided by Ms. Liao, the reporter contacted the maintenance master and asked if it was "after-sales service of Baxi manufacturer". The master said that he was "from Baxi maintenance center".

As a consumer, the reporter dialed the telephone number 4009918883 that Ms. Liao’s husband called for repair at that time. Without telling the brand of home appliances, the wiring customer service claimed to be "a paid maintenance line, and any brand can be repaired, and orders can be received nationwide". After simply asking about the brand of home appliances, the fault situation and the location, the customer service also called itself the "eight-up special hotline" and told the reporter that there would be a master contact later, and the door-to-door fee would be 40 yuan, and the maintenance and replacement of accessories would be counted separately.

Subsequently, the reporter contacted Manager Pang, the after-sales person in charge in Hunan Province, through the after-sales service hotline 4006688700 displayed on Baxi official website. After listening to the reporter’s description, Manager Pang said that the reporter should have encountered a fake after-sales service of Baxi. "The official after-sales hotline is only 4006688700. After the customer reports for repair, he will receive a feedback message, and then the master with authorized service qualification will come to the door. The specific maintenance fee is charged according to the after-sales manual provided by the manufacturer, and formal documents will be issued after the repair."

"I have received many customers’ reports that the level of after-sales personnel in the cottage is uneven, and sometimes it is still minor and overhauled, but we can’t stop it." Manager Pang said helplessly.

The cottage is recommended first after sale.400 telephoneLow threshold for handling

When the reporter searched for the keyword "brand+after-sales" through the mobile phone, he found that many cottage maintenance information ranked in front of the official after-sales information, and was also marked with "national unified customer service hotline" and "headquarters maintenance". Many consumers said that it was difficult to identify if they did not browse carefully.

Why is the false after-sales hotline recommended first? An advertising agent of a search engine told reporters that the display order may be related to advertising bidding ranking and keyword matching, and the information with high price and high fit will be given priority.

Handling the "400" hotline is also very simple. The reporter’s investigation found that on a shopping platform, as long as you provide the business license, legal person ID card and official seal, you can do it with money. The minimum package is one year in 260 yuan, and the annual fee can be fully deducted. 114 can’t find the real information of the company.

Hunan Consumer Protection Committee reminds: Don’t trust the so-called "official maintenance" of online search.

Some insiders said that in recent years, some home appliance enterprises have paid more attention to marketing than after-sales. With the increase of operating costs, the number of regular home appliance repair stores has been decreasing, which has made some cottage repairs have living space, taking advantage of the characteristics of large market demand, low operating threshold, asymmetric information and high difficulty in illegal accountability, and fooling consumers into paying the bill.

In order to prevent consumers from encountering the trap of "cottage" home appliance maintenance, Hunan Consumer Protection Committee reminds consumers that when choosing maintenance services, whether within the warranty period or not, they should first choose the official after-sales service outlets of the purchased brands, and don’t trust the so-called "official maintenance" searched by the Internet; When applying for repair, we should try our best to explain the fault situation so that the door-to-door personnel can take the spare parts and dispose of them in time; After confirming the identity of maintenance personnel, it is necessary to know in detail the charging standards of maintenance projects and whether formal invoices can be issued. If necessary, you can seek technical support from official customer service and understand the official price charging standards; Consumers should collect relevant evidence for the behavior of raising the price or adding maintenance items in the middle of maintenance service, which can be reflected to the official website of the brand, or through relevant government departments and consumer associations to defend their rights.

Jianshi [2019] No.18

Housing and Urban-Rural Development Departments of all provinces and autonomous regions, Human Resources and Social Security Departments, Housing and Urban-Rural Development Committees of municipalities directly under the Central Government, Human Resources and Social Security Bureau, Housing and Urban-Rural Development Bureau of Xinjiang Production and Construction Corps, and Human Resources and Social Security Bureau:

　　The Ministry of Housing and Urban-Rural Development and the Ministry of Human Resources and Social Security have formulated the Measures for the Administration of Real-name System for Construction Workers (Trial) in order to implement the requirements of the Opinions of the General Office of the State Council on Comprehensively Governing the Wage Arrears of Migrant Workers (Guo Ban Fa [2016] No.1) and the Opinions of the General Office of the State Council on Promoting the Sustainable and Healthy Development of the Construction Industry (Guo Ban Fa [2017] No.19). Is issued to you, please combine the actual situation in the region, conscientiously implement.

Ministry of housing and urban-rural development of the people’s Republic of China

ministry of human resources and social security of the people’s republic of china

February 17, 2019

Measures for the administration of real-name system for construction workers (for Trial Implementation)

　　Article 1 In order to standardize the order of the construction market, strengthen the management of construction workers, safeguard the legitimate rights and interests of construction workers and construction enterprises, ensure the project quality and safe production, cultivate professional and skilled construction workers, and promote the sustained and healthy development of the construction industry, in accordance with the Construction Law, the Labor Contract Law, the Opinions of the General Office of the State Council on Comprehensively Governing the Wage Arrears of Migrant Workers (Guo Ban Fa [2016] No.1) and the Opinions of the General Office of the State Council on Promoting the Sustainable and Healthy Development of the Construction Industry,

　　Article 2 The term "real-name registration system of construction workers" as mentioned in these Measures refers to the system of comprehensive management of the employment, training, skills and rights protection of construction workers recruited by construction enterprises by means of authentication of real identity information.

　　Article 3 These Measures shall apply to housing construction and municipal infrastructure projects.

　　Article 4 The Ministry of Housing and Urban-Rural Development and the Ministry of Human Resources and Social Security shall be responsible for formulating the national regulations on the management of real-name system for construction workers, and guiding and supervising the implementation of real-name system management for construction workers in various places; Responsible for organizing the implementation of the planning, construction and management of the national construction worker management service information platform, and formulating the data standard of the national construction worker management service information platform.

　　Article 5 The housing and urban-rural construction departments and human resources and social security departments below the provincial level (autonomous regions and municipalities directly under the Central Government) shall be responsible for the real-name management of construction workers in their respective administrative areas, formulate the real-name management system for construction workers, and urge construction enterprises to fully implement the requirements for the real-name management of construction workers at the construction site; Responsible for establishing and perfecting the real-name management platform for construction workers in this administrative region, ensuring the completeness, timeliness and accuracy of all data, and realizing the communication and sharing with the national construction workers management service information platform.

　　Article 6 The construction unit shall agree with the construction enterprise on the relevant contents of implementing the real-name management of construction workers, urge the construction enterprise to implement various measures for the real-name management of construction workers, create conditions for the construction enterprise to implement the real-name management of construction workers, and pay the wages of construction workers in full and on time to the special account for wages opened by the construction enterprise in the bank according to the progress of the project.

　　Article 7 A construction enterprise shall undertake the responsibility of real-name management of construction workers on the construction site, formulate its own real-name management system for construction workers, equip full-time (part-time) real-name management personnel for construction workers, and upload relevant data to the real-name management platform of construction workers of relevant departments in real time, accurately and completely through information means.

　　General contracting enterprises (including construction general contracting, engineering general contracting and professional contracting enterprises that directly sign contracts with the construction unit according to law, the same below) take overall responsibility for the real-name management of construction workers who undertake the project, while subcontracting enterprises take direct responsibility for the real-name management of construction workers they employ, and cooperate with general contracting enterprises to do relevant work.

　　Eighth full implementation of the real-name management system for migrant workers in the construction industry, adhere to the construction enterprises and migrant workers to sign labor contracts before entering the site for construction. Construction enterprises should sign labor contracts with recruited construction workers according to law, provide them with basic safety training, and register on the real-name management platform of relevant construction workers before allowing them to enter the construction site to engage in activities related to construction operations.

　　Article 9 Project managers such as project leaders, technical leaders, quality leaders, safety leaders, and labor leaders shall bear the corresponding responsibilities for the real-name management of construction workers who undertake the project. Project managers and construction workers of construction units, contractors and supervision units who enter the construction site are all included in the real-name management of construction workers.

　　Tenth construction workers should cooperate with the relevant departments and the real-name management of the construction enterprises, and must sign labor contracts and receive basic safety training before entering the site.

　　Eleventh real-name registration system information of construction workers consists of basic information, employment information, integrity information and other contents.

　　The basic information should include the identity card information, education level, type of work (major), skill level (professional title or post certificate) and basic safety training of construction workers and project managers.

　　Employment information should include jobs, labor contract signing, attendance, salary payment and employment records.

　　Credit information should include credit evaluation, complaint reporting, good and bad behavior records and other information.

　　Twelfth general contracting enterprises should be based on the real identity information, collect the basic information of construction workers and project management personnel entering the construction site, and timely verify and update; Truly and completely record the employment information of construction workers’ jobs, labor contract signing, attendance and salary payment, and establish a real-name management ledger for construction workers; According to the real-name management requirements of construction workers where the project is located, the collected information of construction workers will be uploaded to relevant departments in time.

　　Construction workers who have entered the national construction workers management service information platform and have no data update for more than one year (including one year) shall be re-trained in basic safety when they are engaged in construction work, and relevant information shall be recorded, otherwise they shall not enter the construction site for post work.

　　Thirteenth construction enterprises should be equipped with hardware facilities and equipment necessary to realize the management of construction workers in real-name registration system. In principle, the construction site should be closed, an entrance and exit access control system should be set up, and biometric technologies such as face, fingerprint and iris should be used for electronic punching. Engineering projects that do not have closed management conditions should adopt technologies such as mobile positioning and electronic fence to implement attendance management. Relevant electronic attendance and electronic files such as images and videos shall be kept for at least 2 years.

　　The cost of implementing the real-name management of construction workers can be included in the safety civilized construction measures and management fee.

　　Article 14 A construction enterprise shall, according to the labor contract, directly pay wages to construction workers in full monthly through the special account for wages of migrant workers, and set up a "notice board for rights protection of construction workers" in a prominent position on the construction site to disclose relevant information.

　　Article 15 Housing and urban-rural construction departments at all levels, human resources and social security departments, construction enterprises, system platform development and application units shall formulate systems and take measures to ensure the safety of data and information related to real-name management of construction workers, as well as the authenticity and integrity of real-name registration system information of construction workers, and shall not omit or conceal it.

　　Article 16 Housing and urban-rural construction departments and human resources and social security departments at all levels should strengthen data sharing with relevant departments, establish an early warning mechanism for the protection of construction workers’ rights and interests through data utilization analysis and the use of new media and information technology channels, effectively protect the legitimate rights and interests of construction workers and improve their ability to serve them.

　　Seventeenth housing and urban-rural construction departments at all levels, human resources and social security departments should supervise and inspect the implementation of real-name management of construction workers by lower departments, and order rectification within a time limit for problems found; Refused to rectification or rectification is not in place, to interview the relevant responsible person; After the interview, it still refuses to make rectification or rectification is not in place, which is included in the scope of key supervision and brought to the attention of relevant departments for accountability.

　　Article 18 Housing and urban-rural construction departments at all levels shall, in accordance with the requirements of "double randomness and one openness", strengthen the daily inspection of the implementation of the real-name management system for construction workers at the construction site of their respective administrative areas, and investigate and handle complaints and reports related to the real-name management of construction workers. Those who violate the labor security rights and interests of construction workers, such as not signing labor contracts according to law and unpaid wages, shall be dealt with by the human resources and social security department in conjunction with the housing and urban-rural construction department according to law; Illegal problems or case clues involving the functions of other departments should be transferred in time according to the division of responsibilities.

　　Nineteenth housing and urban-rural construction departments at all levels can include the real-name management of construction workers in the standardized site assessment content. Real-name registration system information of construction workers can be used as the basis for relevant departments to deal with labor disputes of construction workers. All relevant departments should formulate incentive measures to support construction enterprises that effectively implement the real-name management of construction workers. If there is no wage arrears within a certain period of time, the wage deposit for migrant workers can be reduced or exempted.

　　Article 20 The housing and urban-rural construction departments at all levels shall correct the irregularities of enterprises and individuals found in the supervision and inspection, such as fraud, omission and concealment, make rectification within a time limit, enter them into the real-name management platform of construction workers and upload them to relevant departments in time. Refuse to rectify or rectification is not in place, can be dealt with through exposure, verification of enterprise qualifications, etc., there is wage arrears, can increase the proportion of migrant workers’ wage deposit payment, and record related bad behavior in enterprise or personal credit files, and announce it to the public through the national construction market supervision public service platform.

　　Twenty-first it is strictly forbidden for housing and urban-rural construction departments at all levels and human resources and social security departments to designate construction enterprises to purchase related products in the name of implementing the real-name management of construction workers; It is not allowed to arbitrarily charge fees under various pretexts, which will increase the extra burden of enterprises. Those who violate the rules and require construction enterprises to use a certain product or collect fees at random should be corrected immediately; If the circumstances are serious, it shall be submitted to the relevant departments for accountability according to law, and if the case constitutes a crime, criminal responsibility shall be investigated according to law.

　　Twenty-second levels of housing and urban and rural construction departments, human resources and social security departments should be combined with local conditions, formulate the detailed rules for the implementation of these measures.　　

　　Article 23 These Measures shall be interpreted by the Ministry of Housing and Urban-Rural Development and the Ministry of Human Resources and Social Security.

　　Article 24 These Measures shall come into force as of March 1, 2019.

State Taxation Administration of The People’s Republic of China press conference site (photo by Su Yu)

The value-added tax invoice data with a wide penetration is a window to observe the production and operation of market players. According to the data released by State Taxation Administration of The People’s Republic of China on May 28th, in April this year, the sales revenue of national enterprises increased by 12.9% on average for two years, which continued a steady and positive trend.

On the whole, in April this year, the sales revenue of Chinese enterprises continued to grow steadily, the industrial economy continued to recover, consumption and investment steadily improved, and the recovery growth trend of the national economy continued to strengthen.

Zhao Lianwei, deputy director of the Revenue Planning and Accounting Department of State Taxation Administration of The People’s Republic of China, said: "The VAT invoice data shows that in April, the sales revenue of national enterprises increased by 24.6% year-on-year, 27.5% over the same period of 2019, and the average growth rate in two years was 12.9%, continuing the steady and good trend since the second half of last year."

In terms of industrial enterprises, the sales revenue of industrial enterprises increased by an average of 10.1% in two years, reflecting the steady recovery of the industrial economy. Zhao Lianwei said: "Among the 41 major industries, 38 industries have achieved positive growth on average in two years, and 16 industries have achieved an average growth rate of more than 10% in two years."

In the wholesale and retail industry, the sales revenue of the wholesale and retail industry increased by 12.3% on average in two years, one of which is the rapid growth of upgrading consumption. "VAT invoice data shows that in April, the national wholesale and retail sales revenue increased by 26.2% year-on-year, an increase of 26.1% over the same period in 2019, and an average increase of 12.3% in two years. Among them, the consumption of upgrades has grown rapidly, and the retail sales of watches, health care equipment, photographic equipment and nutrition and health products have increased by 21.6%, 46.7%, 9.4% and 25% respectively in two years. " Zhao Lianwei said.

In the construction industry, the sales revenue of the construction industry increased by an average of 14.5% in two years, and the construction of new infrastructure was accelerated. According to the data of VAT invoices, from January to April this year, the sales revenue of the national construction industry increased by 39.6% year-on-year, by 31.1% compared with the same period in 2019, with an average increase of 14.5% in two years, reflecting the continued recovery of investment. The investment structure was gradually optimized, and investment in new infrastructure increased.

In addition, State Taxation Administration of The People’s Republic of China also released the relevant data of newly established tax-related market entities. "Newly established" means that they have gone through the relevant procedures for the registration of market entities, and "tax-related" means that certain production and business activities have taken place. The data shows that thanks to the continuous release of a series of policy dividends, such as tax reduction and fee reduction, "streamline administration, delegate power, strengthen regulation and improve services" reform, and optimization of business environment, in April, there were 1.336 million new tax-related market entities, an increase of 5.1% compared with March, an increase of 21% and 20.3% respectively compared with the same period in 2020 and 2019, with an average increase of 9.7% in two years.

In terms of types, the number of newly-established individual industrial and commercial households reached 621,000, which is about half of the total number of newly-established businesses. The executive meeting of the State Council made it clear that we should continue to provide targeted support to small and micro enterprises and individual industrial and commercial households, including implementing tax reduction and fee reduction measures and helping them cope with the impact of rising prices of raw materials.

　Fan Chunhai is a member of the Central Committee of Jiu San Society, a professor at the School of Chemistry and Chemical Engineering of Shanghai Jiaotong University, and a member of the Shanghai Municipal Political Consultative Conference. In 2019, he was co-elected as an academician of China Academy of Sciences.

At the age of 26, he received a doctorate in biochemistry and molecular biology from Nanjing University.

At the age of 33, he was supported by the Outstanding Youth Fund of the National Natural Science Foundation of China.

At the age of 42, his team developed a new method for inducing nano-scale precise mineralization by DNA self-assembly structure, which was published in Nature, and achieved the first breakthrough in the field of DNA nanotechnology by China researchers.

He has been selected as a "highly cited scientist in the world" in the past six years.

At the age of 45, he was elected as an academician of China Academy of Sciences, the youngest among the Shanghai academicians in 2019.

He is Fan Chunhai, member of the Central Committee of the Jiu San Society, member of the Shanghai Municipal Committee of the Chinese People’s Political Consultative Conference, and director of the Shanghai Municipal Committee of the Jiu San Society.

Fan Chunhai’s office is located in the Translational Medicine Research Center of Shanghai Jiaotong University. Next to the simple and bright office is a uniform laboratory. The experimental platform is filled with all kinds of equipment. The window is bright and clean, with few other colors except black and white. Fan Chunhai, who has just been interviewed by his alma mater, is still immersed in the memories of middle school life. Talking about today’s achievements, he said with emotion: "These 20 years happened to be a period of rapid development in China, and the conditions and level of scientific research have undergone tremendous changes. I am glad to catch up with such a good era and let me make great achievements in scientific research."

Fan Chunhai belongs to the Ministry of Chemistry in the published results of the co-election of academicians of China Academy of Sciences. He once won the Tan Jiazhen Prize for Innovation in Life Sciences, one of the most influential awards in the field of life sciences in China. After returning to China, he chose the Shanghai Institute of Applied Physics of Chinese Academy of Sciences as his work unit. Under such a "cross-border", it seems difficult to define his professional field. His explanation for this is: "Subject field and research direction are different concepts, and my research direction has not changed for more than 20 years. I have been engaged in basic research on biosensing since I was a graduate student, just to explore the unknown world and need a broader vision. "

In 1992, Fan Chunhai, who was preparing to take the college entrance examination, applied for the Department of Biochemistry of Nanjing University. "At that time, the choice of biochemistry was blind and I didn’t understand it at all. But I vaguely feel that biochemistry has both biology and chemistry. This name is cool! " Fan Chunhai recalled.

樊春海在南京大学读书时，生物化学系就有浓郁的学科交叉氛围，系里的口号是“学不好化学，就做不好生物化学”。我国生物制药技术研发的开拓者之一，肝素、尿激酶工业的创始人朱德煦时任系主任，中国科学院院士、生命分析化学概念的创导者和生命分析化学国家重点实验室创始人陈洪渊的博士李根喜在生物化学系任教，樊春海在研究生期间得到他们的指导，在生物化学和生命分析化学两条学术传承线的交叉点起步，从事电化学生物传感器的研究，这在当时属于前沿交叉学科。

在前沿学科里不断前进，必须更多地了解国际上的科研动态，“我读书那会儿，经常需要看国外文献，遗憾的是那时看到的文献会滞后至少半年。”樊春海偶然读到《先进材料》（Advanced Materials）杂志对圣塔芭芭拉加州大学（UCSB）艾伦？黑格（Alan J. Heeger）教授（诺贝尔化学奖获得者）的专访文章。文章中黑格表示，自己在获诺贝尔奖后希望做一些以往不敢做的事，比如生物学，特别是生物传感方面的研究。樊春海内心有种一拍即合的快感，随即就向黑格教授申请了博士后，并最终获得认可。

Allen? Haig is a professor in the Department of Physics, but he always advocates interdisciplinary research. Many years later, Professor Haig said modestly in a speech in China: "I knew nothing about biology at that time, even the most basic knowledge such as DNA molecular structure was taught by Chunhai."

"Studying in a Nobel Prize winner’s laboratory, the vision of seeing problems and the way to deal with problems are very different from those in an ordinary laboratory." Fan Chunhai admits that when he was working as a postdoctoral fellow, he realized a deeper connotation about interdisciplinary. Working in Haig’s laboratory, Fan Chunhai had to carry out multiple scientific research projects at the same time, which once overwhelmed him. "You just pick the most important thing to do." This sentence of the tutor made Fan Chunhai enlightened, and he still often guides him to make judgments.

Under the guidance of Professor Haig, Fan Chunhai has made some research progress, and related research work has been published in authoritative magazines such as Proceedings of the National Academy of Sciences (PNAS) and Journal of the American Chemical Society (JACS). Among them, an electrochemical DNA biosensor named E-DNA has been developed, which has been widely praised by international peers. American Chemical Society C&E News rated it as one of the important chemical progress in 2003.

The postdoctoral experience has greatly broadened Fan Chunhai’s horizons and strengthened his confidence in interdisciplinary research. At that time, China was in the initial stage of discipline construction and needed a lot of new blood. In January 2004, Fan Chunhai joined sinap with the support of the "Hundred Talents Program" of China Academy of Sciences. Coincidentally, the day when he joined the defense was the day when the Shanghai Synchrotron Radiation Light Source Project undertaken by the Institute was approved after ten years of hard preparation. This internationally advanced synchrotron radiation light source was completed in only five years. The scientists who participated in the project are not afraid of hardships and hard work, and are praised as "Shanghai Light Source Spirit". In the past five years, under the inspiration of "Shanghai Light Source Spirit", Fan Chunhai built a laboratory from scratch.

In 2008, Fan Chunhai and others established a physical biology laboratory and set up a multidisciplinary research team integrating physics, chemistry and biology. This unique interdisciplinary research atmosphere not only enabled the biosensor research to advance rapidly, but also broadened more frontier research directions. In 2016, the important achievement of the laboratory, "Research on Mechanism, Regulation and Application of Biomolecular Interface", won the second prize of National Natural Science.

In recent years, Fan Chunhai’s team has applied biosensing probes detected in vitro to cells, and is committed to developing frame nucleic acid cell imaging technology. "It doesn’t matter what technology you use, physics or chemistry, or nanotechnology. What matters is that you find some new methods and use some new technologies to observe and decipher the mysteries of life."

"Individual growth cannot be separated from excellent collectives"

Fan Chunhai always appreciates the strength of the collective. Whether it is the study and life in middle schools and universities or the scientific research work, Fan Chunhai believes that the excellent collective has given him the motivation for personal growth.

He recalled that he was never the best student in middle school. "I am a person who knows by learning, not a person who knows by birth." In high school, many of my classmates were excellent. Everyone always discussed problems harmoniously and equally, forming a rich learning atmosphere. Under the professional guidance of teachers, everyone was growing and making progress. In the end, the whole class handed over an excellent answer sheet in the college entrance examination. "

There is such a collective star effect in scientific research, such as the famous Cavendish laboratory, which has trained more than 20 Nobel Prize winners in the past 100 years. "So scientific research has never been alone, and the progress of each group cannot be separated from individual efforts, and the growth of individuals cannot be separated from an excellent group." Fan Chunhai said.

At the beginning of this century, the scientific research conditions in Chinese universities were still relatively difficult, and the information was not as developed as it is now. It was the dream of many analytical chemists in China to be able to publish papers in Analytical Chemistry in the United States. At that time, only Mr. Chen Hongyuan in Nanjing University published papers in this magazine. Fan Chunhai published a paper in Analytical Chemistry as the first author under the guidance of his tutors, and achieved a breakthrough.

Interdisciplinary cooperation is also inseparable from the cooperation between scientists and the whole team. Fan Chunhai, deeply inspired by the "Shanghai Light Source Spirit", hopes to do the same internationally influential research work in Shanghai Institute of Applied Physics, Chinese Academy of Sciences. Mr. Li Mingan and researcher Hu Jun are early explorers in the cross-research of nano-organisms in China. With their guidance and help, Fan Chunhai gradually made it clear that DNA nanotechnology is the starting point to form research characteristics.

DNA nanotechnology is to use the excellent self-assembly and recognition ability of DNA molecules as a nano-material to achieve accurate nano-construction. In 2006, the nano-scale "Map of China" assembled by DNA molecules was successfully created and published in both Chinese and English editions of Science Bulletin, which made an international appearance with China characteristics and became the second published work in the frontier cross field of "DNA origami", which was jointly completed by Fan Chunhai, Hu Jun and Academician He Lin of Shanghai Jiaotong University.

After years of accumulation, Fan Chunhai’s team developed a new method to induce nano-scale precise mineralization by DNA self-assembly structure, which improved the mechanical properties of DNA nano-structure while maintaining its exquisite design, and opened a new door for the construction and analysis of bionic nano-channels. This research achievement was published in the journal Nature, which achieved the first breakthrough in this field by researchers in China.

During the epidemic in COVID-19, due to the lack of Covid-19 RNA reference materials, the performance of nucleic acid detection kits could not be evaluated, and the competitiveness of high-quality domestic kits could not be strongly proved. Faced with this situation, with the deep participation and support of Fan Chunhai’s team, Shanghai Jiaotong University and Shanghai Institute of Metrology and Testing Technology jointly set up a research team and started the research and development project of Covid-19 RNA reference materials. After more than 40 days of repeated trials and improvements, two kinds of "novel coronavirus standard materials for RNA transcription in vitro" were successfully developed. These Covid-19 reference materials, like a "biological standard ruler", can help people to evaluate the indicators of the virus nucleic acid detection kit and help the detection laboratory to confirm the results, thus further reducing the probability of "false negative".

Facing the students from different majors in the team, Fan Chunhai advocates teaching students in accordance with their aptitude and effective guidance. "Students are not managed, but grow up freely under appropriate guidance. My task is to tap students’ interest in scientific research, help them establish correct values and lofty aspirations, and become firm supporters of students."

The road of scientific research has always been bumpy. The life of researchers is more like an ascetic monk to many people, but in their hearts, they are happy because of their love for science. In Fan Chunhai’s view, this happiness is not equal to comfort. He encourages students: "To do scientific research, we should be brave enough to go out of our comfort zone and challenge new things."

"Teamwork and independent thinking are equally important. I hope that every student can choose his own topic under the background of team research, and actively explore various possibilities without relying on authority." Despite his busy work, Fan Chunhai will try his best to take time to communicate with the students face to face, not sitting in danger, but full of relaxation and pleasure.

Fan Chunhai always tries his best to support and encourage students’ decisions and every attempt. Under his training, two students have been supported by the National Science Fund for Distinguished Young Scholars, and four postdoctoral students have been selected for the "Super Postdoctoral Program" in Shanghai in 2020.

Communication and cooperation promoted Fan Chunhai’s scientific research work, and also made him know Li Xinxin, chairman of the Shanghai Branch Committee of the Shanghai Municipal Committee of the Chinese Academy of Sciences of the Jiu San Society. The warmth of the Jiu San Society and the spirit of patriotism, democracy and science attracted him. In 2014, he joined the Jiu San Society.

After joining the club, Fan Chunhai successively served as deputy director and director of the Shanghai Municipal Committee of the Jiu San Society. Although his scientific research work is still busy, he will still find time to engage in popular science work. "Popular science work is actually a kind of inheritance. Whether it is exploring the unknown world or promoting the country’s scientific and technological development, it needs the efforts of generations. However, the concept of scientific research is not exactly the same as that of textbook education in primary and secondary schools. Our popular science work is not a simple strengthening of textbook knowledge, but a broader vision for children. "

In his mind, interests are hierarchical. The interests of primary and secondary school students are often in textbook knowledge and the use of known world knowledge, while real scientific talents need to keep their interest in exploring the unknown world. Spreading the seeds of science in children’s little hearts will not only keep them interested in exploring the unknown world, but also make the city form an atmosphere of obeying and respecting science, which is also the future light of the construction of Shanghai Science and Technology Innovation Center.

Looking back on his own growth experience, Fan Chunhai said with emotion: the cultivation of quality is more important, and the knowledge learned by the school is constantly updated, and the quality cultivated by the school will accompany people all their lives, and good quality will push people forward.

Good quality also made Fan Chunhai on his way to school recognized by teachers. "I am very relieved about what I have told him. No matter whether I get satisfactory results or lessons from failure after completion, he will definitely reply to me and have a serious discussion with me." Professor Li Genxi said of his students, "He is patient in learning and can hold his breath. Once his goal is set, he will be firm and forge ahead. His success is no accident."

In the interview, Fan Chunhai rarely talked about specific difficulties, because he believed that difficulties always existed, and problems could be solved as long as he worked hard and was good at learning and observing. In the communication with his students, Fan Chunhai has always conveyed a belief: optimistic and unyielding. "The development of science is not a full stop, but a comma. The success of scientific research depends on whether you have the courage to face failure and the determination to be more frustrated on the road of exploration. I hope that all students can work hard for the scientific dream of mankind."

It has been nearly thirty years since I entered the university and contacted the interdisciplinary subject of biochemistry. Along the way, Fan Chunhai has grown from an ignorant teenager to an internationally renowned scientist: he was selected as a Fellow of American Association for the Advancement of Science (AAAS), American Academy of Medical and Biological Engineering (AIMBE), international society of electrochemistry (ISE) and royal society of chemistry (RSC), and concurrently served as the deputy editor of ACS Applied Materials & Interfaces Journal of American Chemical Society. Co-chairman of the editorial board of ChemPlusChem, royal society of chemistry, has been selected as a "global highly cited scientist" continuously since 2014. In 2019, he was elected as an academician of China Academy of Sciences, and won the ho leung ho lee foundation Science and Technology Innovation Award, the American Chemical Society’s Lecture Award for Progress in Measurement Science and the 12th Tan Jiazhen Life Science Innovation Award, and in 2020, he was awarded the title of "National Advanced Worker".

Faced with many honors, Fan Chunhai said calmly: "It is curiosity, responsibility and initial heart that lead me to climb to the peak on the road of science." In the future, he said that he will continue to keep his initial heart and forge ahead, lead students to "look up at the stars, be down-to-earth, persevere and make contributions for a long time", constantly explore the frontiers of science, and make due efforts to promote the scientific and technological progress of the country and society.

Fan Chunhai’s goal is to promote his basic research work to clinical application and protect human health. After joining the School of Chemistry and Chemical Engineering of Shanghai Jiaotong University, Fan Chunhai built the laboratory of "Framework Nucleic Acid Design and Nano-medical Diagnosis and Treatment" based on the newly completed national major scientific and technological infrastructure of translational medicine, and devoted himself to transforming and applying the developed new methods of nucleic acid analysis and detection to clinic. In particular, he received the full support of Academician Tan Weihong, Dean of the Institute of Molecular Medicine of Shanghai Jiaotong University, and actively carried out clinical cooperation in Renji Hospital, trying to apply biosensors to the detection of practical clinical samples such as prostate cancer, and exploring the possibility of developing low-cost medical detection.

"The road is long and Xiu Yuan is awkward, and I will search up and down." Fan Chunhai is still moving forward on the road of seeking. In 2019, in order to commemorate the tenth anniversary of the publication, "Nature? The magazine Nature Chemistry specially invited more than 50 internationally renowned scholars to write a monograph on "The Road to Chemistry". As one of them, Fan Chunhai raised a challenging question in the field of chemistry: "An exciting frontier of the discipline is to understand how artificially designed nucleic acid structures are assembled and function in living cells and animals. Creating new tools to control the assembly process of natural and artificial nucleic acid molecules in living cells will probably bring revolutionary changes to the field of nucleic acid chemistry, thus promoting the development of nano-diagnosis and treatment and precision medicine. In the longer term, another promising research direction is to explore and develop DNA or RNA robots with artificial intelligence and work in animals and humans. " (Huang yun)

　　There are three ways to upgrade the sogou input method: 【 Manual Update 】 means not to update, and click 【 Update Now 】 to update yourself. [Prompt Update] is to prompt when there is a new version. Automatic update is to download and install the updated new version automatically when a new version is found.

　　Sogou input method is a Chinese Pinyin input method recently launched by Sohu, which is a great breakthrough compared with Intelligent ABC and Microsoft Pinyin input method. First of all, it has increased a lot in the thesaurus. The sogou input method includes the most popular phrases, including the names of famous stars, into the thesaurus by analyzing a large number of web pages, so that the phenomenon that commonly used phrases can’t be typed is no longer seen. Secondly, the interface has also been greatly improved. Chinese characters will be automatically displayed below the typed letters, and it is no longer necessary to press the space bar. More convenient input and faster typing speed are the main features of sogou input method.

　　Sogou input method is different from the traditional method in that it adopts search engine technology, which is the second generation input method. Thanks to the adoption of search engine technology, the speed has made a qualitative leap, and sogou is far ahead of other input methods in terms of the breadth of thesaurus and the accuracy of words.

　　The biggest feature of sogou input method is the combination of input method and Internet. The input method will automatically update its own popular thesaurus, which is derived from the popular keywords of sogou search engine. In this way, the workload of users’ self-created words is reduced and the efficiency is improved.